Our main research interests lie within the overlapping fields of RNA structure and function, protein-nucleic acid interactions, and protein synthesis. The work is concentrated on tRNA and tmRNA, two small RNA molecules which play an important role in protein synthesis and trans-translation.
Dr. Jacek Wower
Associate Professor of Biochemistry
Program in Cell and Molecular Biosciences
Department of Animal and Dairy Sciences
209 Upchurch Hall
Auburn University
Auburn, AL 36849-5415Tel: (334) 844-1508 (office) or (334) 844-1554 (lab)
Fax: (334) 844-1519
e-mail: jwower@acesag.auburn.edu
Research
Wower, J., Wower, I.K., Kraal, B., and Zwieb, C.W. (2001) Quality Control of the Elongation Step of Protein Synthesis by tmRNP. J. Nutrition, November, in press .Recent Publications (selected)
Zwieb, C., Guven, S.A., Wower, I.K. and Wower, J. (2001) Three-Dimensional Folding of the tRNA-like Domain of Escherichia coli tmRNA. Biochemistry 40, 9587-9595.
Mansaur, M.M., Machen, M.R., Tarleton, B.J., Wiley, A.A., Wower, J., Bartol. F.F. and Goyal, H.O. (2000) Expression and Molecular Characterization of Estrogen Receptor Alpha (Era) mRNA in the Male Reproductive Organs of Adult Goats. Reproductive Biology 64, 1432-1438.
Knudsen, B., Wower, J., Zwieb, C. and Gorodkin, J. (2001). tmRDB (tmRNA database) Nucleic Acids Res. 29, 171-172.
Wower, J., Kirillov, S.V., Wower, I., Guven, S., Hixson, S.S., and Zimmermann, R.A. (2000) Transit of tRNA through the Escherichia coli Ribosome: Cross-linking of the 3' End of tRNA to Specific Nucleotides of the 23S Ribosomal RNA at the A, P and E Sites, J. Biol. Chem., 275(48), 37887-37894.
Wower, I.K., Zwieb, C.W., Guven, S.A. and Wower, J. (2000) Binding and Cross-linking of tmRNA to Ribosomal Protein S1 on and off the Escherichia coli Ribosome: Implications for tmRNA Function. EMBO J., 19(23), 6612-6621.
Zwieb, C. and Wower, J. (2000). tmRDB (tmRNA database).Nucleic Acids Res 28(1): 169-170.
Barends, S., Wower, J. and B. Kraal (2000). Kinetic parameters for tmRNA binding to alanyl-tRNA synthetase and elongation factor Tu from E. coli. Biochemistry 39, 2652-2658.
Wower, C. Zwieb, and I. Wower (2000) tmRNA: A Case of Structural and Functional Mimicry on and off the Ribosome. In: The Ribosome (R. A. Garrett, ed.), ASM Press, 397-405.
Wower, J., Wower, I and Zwieb, C. (1999) An Extended Hybrid Model for Translocation of tRNA and the Peptidyl Transferase of the Escherichia coli Ribosome. Nucleic Acids Symposium 41, 187-191.
Zwieb, C. and Wower, J. (2000) The tmRNA Database (tmRDB), Nucleic Acids Res. , in press (see attached letter from editor).
Zwieb, C., Florian Muller, and Wower, J. (1999) Comparative Three-Dimensional Modeling of tmRNA. Nucleic Acids Symposium 41, 200-204.
Zwieb, C., Wower, I.K. and Wower, J. (1999) Comparative Sequence Analysis of tmRNA Nucleic Acids Res., 27(10), 2063-2071.
Wower, J. and Zwieb, C. (1999) The tmRNA Database (tmRDB), Nucleic Acids Res. 27(1), 167-168.
Bartol, F.F., Zorn, C.E., Mulvaney, D.R. and Wower, J. (1999) Animal Biotechnology: Challenges and Opportunities in the Real World. Proceedings of the Auburn University Agricultural Conference, 16-23.
Wower, I.K., Wower, J., Zimmermann, R.A. (1998) Ribosomal Protein L27 Participates in Both 50S Subunit Assembly and the Peptidyl Transferase Reaction. J. Biol. Chem. 273(31), 19847-19852.
Zwieb, C., Larsen, N., and Wower, J. (1998) The tmRNA Database (tmRDB), Nucleic Acids Res. 26(1), 166-167.
Wower, J., Wower, I.K., Kirillov, S., Rosen, K., Hixson, S.S. and Zimmermann, R.A. (1996) Peptidyl Transferase and Beyond. Biochemistry and Cell Biology 73, 1041-1047.
Wower, J., Rosen, K.V., Hixson, S.S., and Zimmermann, R.A. (1994) Recombinant Photoreactive tRNA Molecules as Probes for Cross-linking Studies, Biochimie 76, 1235-1246.
Sylvers, L.A., and Wower, J. (1993) Nucleic Acid-Incorporated Azidonucleotides: Probes for Studying the Interaction of RNA or DNA with Proteins and other Nucleic Acids, Bioconjugate Chemistry 4, 411-418.
Wower, J., Scheffer, P., Sylvers, L.A., Wintermeyer, W. and Zimmermann,
R.A. (1993) Identification of Ribosomal Components at the Ribosomal E site
by Cross-linking to Photoreactive tRNAPhe Derivatives, EMBO J. 12(2), 617-623.
tmRNA database (Auburn University/mirror site)
tmRNA database (University of Texas Health Center at Tyler, TX)
Other useful links
The
tmRNA Website
The RNA Society
Courses Taught
Biochemistry (ANSC 618; 5h; Fall) Classification,
structure and chemistry of the major chemical constituents of living matter
Proteins (ANSC 741; 5h; Spring) Chemical and physical
properties of amino acids and proteins, protein structures and the relation
of protein structure to function
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