In silico identification and expression analysis of 12 novel CC chemokines in catfish

Year:
2005
Journal:
Immunogenetics
Volume:
57
Pages:
409-419
Author:
Peatman, Eric;Bao, ;Baoprasertkul, ;Liu, Zhanjiang
Category:
Genetics
Pub ID:
1715
Abstract:
Chemokines, a superfamily of chemotactic cytokines
involved in recruitment, activation, and adhesion of a
variety of leukocyte types to inflammatory foci, are a crucial
component of the immune system of Sarcopterygiian
vertebrates. Although all mammalian chemokines are believed
to have been found, the status of these molecules in
Actinopterygii was unknown until recently. The identification
of chemokines in fish species has been complicated by
low sequence conservation and confusion over expected
numbers. Earlier discoveries of single fish chemokines
coupled with rapidly expanding genetic resources in these
species have recently provided a foundation for large-scale
in silico discoveries of these important immune regulators.
We report here the identification and expression analysis
of 12 new CC chemokine sequences from catfish. When
added to our previous report of 14 catfish CC chemokines,
the number of CC chemokines in catfish now stands at 26,
two more than known from humans. Establishing orthologous
relationships among the majority of catfish CC
chemokines, a newly available set of chicken CC chemokines,
and their mammalian counterparts remain difficult,
suggesting high levels of duplication and divergence
within individual species.
PDF File:
Eric Peatman CC chemokine Immunogenetics paper.pdf

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